Frequency patterns of T-cell exposed motifs in immunoglobulin heavy chain peptides presented by MHCs
Immunoglobulins are highly diverse protein sequences that are processed and presented to T-cells by B-cells and other antigen presenting cells.We examined a large dataset of immunoglobulin heavy chain variable regions (IGHV) to assess the diversity of T-cell exposed motifs (TCEM).TCEM comprise those amino acids in a MHC-bound peptide which face out